石杉碱甲改善老年痴呆症的药效学研究

食品科学 ›› 2007, Vol. 28 ›› Issue (5): 327-331.

石杉碱甲改善老年痴呆症的药效学研究

雍彬, 刘建廷, 张晓喻, 黄春萍, 黎艳, 严伟

四川师范大学生命科学学院；四川师范大学生命科学学院四川成都610068；四川成都610068；

出版日期:2007-05-15 发布日期:2011-12-31

Study on Pharmacodynamics of Alzheimers Disease with Hupzine A

YONG Bin, LIU Jian-Ting, ZHANG Xiao-Yu, HUANG Chun-Ping, LI Yan, YAN Wei

College of Life Science,Sichuan Normal University,Chengdu 610068,China

Online:2007-05-15 Published:2011-12-31

摘要/Abstract

摘要： 本研究采用跳台法和避暗法观察了三个剂量(13．5、41．0、61．0μg／kg)的石杉碱甲对三种记忆障碍小鼠记忆能力的影响。研究结果表明:石杉碱甲能明显地提高小鼠跳台被动回避反应再现能力和提高避暗反应再现能力。由此可知,石杉碱甲有促进记忆,改善老年痴呆症症状的作用。

关键词: 石杉碱甲, 改善老年痴呆症

Abstract: In this paper,the effects of mice memory were studied merely by jumping platform experiment and avoiding darkness experiment with three doses respectively as 13.5,41.0 and 61.0μg/kg hupzine A.The results showed that hupzine A has the obvious effects on improving both the reappearance ability of passive avoidance and the avoiding darkness response.So hupzine can have the function to promote memory and improvement symptom of Alzheimers disease.

Key words: hupzine, improvement symptom of Alzheimers disease

雍彬, 刘建廷, 张晓喻, 黄春萍, 黎艳, 严伟. 石杉碱甲改善老年痴呆症的药效学研究[J]. 食品科学, 2007, 28(5): 327-331.

YONG Bin, LIU Jian-Ting, ZHANG Xiao-Yu, HUANG Chun-Ping, LI Yan, YAN Wei. Study on Pharmacodynamics of Alzheimers Disease with Hupzine A[J]. FOOD SCIENCE, 2007, 28(5): 327-331.