普洱熟茶对糖脂代谢异常改善效果的临床研究

doi:10.7506/spkx1002-6630-20230929-261

食品科学 ›› 2024, Vol. 45 ›› Issue (12): 144-156.doi: 10.7506/spkx1002-6630-20230929-261

• 营养卫生 • 上一篇

普洱熟茶对糖脂代谢异常改善效果的临床研究

孙颖，李艳，王黎明，侯粲，郝彬秀，李颂，孙婷婷，祁敬杰，钟丽娣，杜琴，许伟坚，陈再强，田波，黎海莹，应剑，陈玉华，魏珍珍

（1.中粮营养健康研究院有限公司，北京 102209；2.营养健康与食品安全北京市重点实验室，北京 102209；3.香港中文大学（深圳）附属第二医院&深圳市龙岗区人民医院内分泌代谢科，广东深圳 518172；4.中茶科技（北京）有限公司，北京 102209；5.云南中茶茶业有限公司，云南昆明 650000；6.香港中文大学（深圳）附属第二医院&深圳市龙岗区人民医院影像科，广东深圳 518172；7.香港中文大学（深圳）附属第二医院&深圳市龙岗区人民医院健康教育科，广东深圳 518172；8.广东医科大学附属医院，广东湛江 524002）

发布日期:2024-07-10
基金资助:
航天育种和航天食品研发与示范项目（202202AE090001）；世界大叶茶技术创新中心建设及成果产业化项目（202102AE090038）； 2022年度龙岗区医疗卫生科技计划项目（非扶持）（LGWJ2022-26）；3T普洱茶调节糖脂代谢功效人群研究项目

Clinical Trial on the Effect of Ripened Pu-erh Tea on Improving Abnormal Glucose and Lipid Metabolism

SUN Ying, LI Yan, WANG Liming, HOU Can, HAO Binxiu, LI Song, SUN Tingting, QI Jingjie, ZHONG Lidi, DU Qin, XU Weijian, CHEN Zaiqiang, TIAN Bo, LI Haiying, YING Jian, CHEN Yuhua, WEI Zhenzhen

(1. Nutrition and Health Research Institute, COFCO Ltd., Beijing 102209, China; 2. Beijing Key Laboratory of Nutrition & Health and Food Safety, Beijing 102209, China; 3. Endocrinology Department of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People’s Hospital of Shenzhen, Shenzhen 518172, China; 4. China Tea Technology (Beijing) Co. Ltd., Beijing 102209, China; 5. China Tea (Yunnan) Co. Ltd., Kunming 650000, China; 6. Medical Imaging Department of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People’s Hospital of Shenzhen, Shenzhen 518172, China; 7. Health Education Department of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People’s Hospital of Shenzhen, Shenzhen 518172, China; 8. Affiliated Hospital of Guangdong Medical University, Zhanjiang 524002, China)

Published:2024-07-10

摘要/Abstract

摘要： 本实验探讨了一款普洱熟茶对糖脂代谢异常人群的健康改善作用。该茶为云南中茶茶业有限公司的上市产品Y562普洱熟茶，招募合格试饮志愿者，采用营养流行病学临床干预研究设计，试饮该茶3 个月，通过检测及对比志愿者试饮前后的人体成分（体质量、身体质量指数、体脂比、内脏脂肪）、身体围度（腰围、臀围、颈围）、糖代谢相关指标（空腹血糖、胰岛素、C肽、糖化血红蛋白）、脂代谢相关指标（总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白A1和B）、血尿酸、肝脏脂肪量和肠道菌群等各项指标，探讨该普洱熟茶的健康功效。结果显示，试饮Y562普洱熟茶3 个月后，饮食和运动不变的情况下，志愿者的体质量、身体质量指数、身体围度（腰围、臀围、颈围）、血脂（高密度脂蛋白胆固醇、载脂蛋白A1和B）和肝脏脂肪量均显著改善（P＜0.05）；血糖（空腹血糖、胰岛素、C肽、胰岛素抵抗、糖化血红蛋白）、血甘油三酯、血尿酸均有改善，但差异没有统计学意义（P＞0.05）；肠道菌群改善，均匀性增加，Lactobacillus、Clostridium、Akkermansia muciniphila、Clostridium scindens、Streptococcus thermophilus等菌属/种相对丰度升高，Streptococcus、Lactococcus、Bacteroides、Bifidobacterium、Parabacteroides distasonis等菌属/种相对丰度降低。研究提示Y562普洱熟茶具有辅助减肥、改善体型、降血糖、降血脂、改善非酒精性脂肪肝的作用，预测内在机制可能与普洱熟茶调节肠道微生态及胆汁酸通路相关。

关键词: 普洱熟茶；糖脂代谢；肠道菌群；胆汁酸

Abstract: This study explored the effect of commercial ripened Pu-erh tea (Y562, China Tea (Yunnan) Industry Co. Ltd.) on improving the health of populations with abnormal glucose and lipid metabolism. Qualified volunteers were recruited for nutritional epidemiological and clinical intervention studies. The volunteers were asked to drink the tea for three months. Their body composition (body mass, body mass index (BMI), body fat ratio and visceral fat), body circumferences (waist circumference, hip circumference and neck circumference), glucose metabolism-related indicators (fasting blood glucose, insulin, C-peptide, glycosylated hemoglobin), lipid metabolism-related indicators (total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A1 and B), blood uric acid levels, liver fat contents, and gut microbiota were tested and compared before and after drinking the tea to explore its health benefits. The results showed that after drinking Y562 without any change in diet or exercise for three months, the body mass, BMI, body circumferences, blood lipids (high-density lipoprotein cholesterol, apolipoprotein A1 and B), and liver fat contents of the volunteers were significantly improved (P < 0.05). Blood glucose (fasting blood glucose, insulin, C-peptide, insulin resistance, and glycosylated hemoglobin), triglyceride, and uric acid levels were also improved, but without any statistical significance (P > 0.05). Moreover, the gut microbiota was improved, showing increased uniformity. The relative abundance of Lactobacillus, Clostridium, Akkermansia muciniphila, Clostridium screenens and Streptococcus thermophilus was increased, while that of Streptococcus, Lactococcus, Bacteroides, Bifidobacterium and Paraacteroides distasonis was decreased. This study suggests that ripened Pu-erh tea Y562 has the potential to help reduce the body mass, improve the body shape, reduce blood glucose and lipids, and alleviate non-alcoholic fatty liver disease (NAFLD). The underlying mechanism may be related to the regulation of the intestinal microecology and the bile acid pathways by Pu-erh tea.

Key words: ripened Pu-erh tea; glucose and lipid metabolism; gut microbiota; bile acids

中图分类号:

TS201.4

孙颖，李艳，王黎明，侯粲，郝彬秀，李颂，孙婷婷，祁敬杰，钟丽娣，杜琴，许伟坚，陈再强，田波，黎海莹，应剑，陈玉华，魏珍珍. 普洱熟茶对糖脂代谢异常改善效果的临床研究[J]. 食品科学, 2024, 45(12): 144-156.

SUN Ying, LI Yan, WANG Liming, HOU Can, HAO Binxiu, LI Song, SUN Tingting, QI Jingjie, ZHONG Lidi, DU Qin, XU Weijian, CHEN Zaiqiang, TIAN Bo, LI Haiying, YING Jian, CHEN Yuhua, WEI Zhenzhen. Clinical Trial on the Effect of Ripened Pu-erh Tea on Improving Abnormal Glucose and Lipid Metabolism[J]. FOOD SCIENCE, 2024, 45(12): 144-156.

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普洱熟茶对糖脂代谢异常改善效果的临床研究

Clinical Trial on the Effect of Ripened Pu-erh Tea on Improving Abnormal Glucose and Lipid Metabolism

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