食品科学 ›› 2025, Vol. 46 ›› Issue (13): 28-31.doi: 10.7506/spkx1002-6630-20241230-253

• 植物化合物生物合成专栏 • 上一篇    

微生物合成酪氨酸衍生物的代谢途径调控策略研究进展

周丹丹,马营,刘英杰   

  1. (齐鲁理工学院生物与化学工程学院,山东 济南 250200)
  • 发布日期:2025-06-13
  • 基金资助:
    齐鲁理工学院科研计划项目(QIT24TP038)

Recent Advances in Regulatory Strategies of Metabolic Pathways for Microbial Synthesis of Tyrosine Derivatives

ZHOU Dandan, MA Ying, LIU Yingjie   

  1. (College of Biological and Chemical Engineering, Qilu Institute of Technology, Jinan 250200, China)
  • Published:2025-06-13

摘要: 多种酪氨酸衍生物因具有食用特性和药用价值被广泛应用于食品、医药和化工等领域,基于此,开发高值酪氨酸化合物的环保高效型获取方式成为研究热点。随着合成生物学和代谢工程的发展,利用微生物细胞工厂合成高值酪氨酸衍生物有望成为绿色大规模化生产方式,其中调控目的产物的代谢途径对提升生产效率至关重要。因此,本文介绍了酪氨酸衍生物的合成途径及代谢调控策略,为构建高产工程菌株提供参考。

关键词: 细胞工厂;酪氨酸衍生物;合成路径;代谢途径调控策略

Abstract: Tyrosine derivatives are widely used in the fields of food, medicine and chemical engineering due to their important edible and medicinal values. Based on this, the development of green and efficient methods for obtaining high-value tyrosine derivatives has become a research hotspot. With the development of synthetic biology and metabolic engineering, using microbial cell factories to synthesize high-value tyrosine derivatives is expected to become a green and large-scale production method. Besides, regulating the metabolic pathways of the target products is crucial to improving the production efficiency. Therefore, this article introduces the synthetic pathways and metabolic regulation strategies of tyrosine derivatives, hoping to provide a reference for constructing high-yield engineered strains.

Key words: cell factory; tyrosine derivatives; synthesis pathway; regulatory strategies of metabolic pathways

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