怀山药对小鼠学习记忆能力的影响

doi:10.7506/spkx1002-6300-201003056

食品科学 ›› 2010, Vol. 31 ›› Issue (3): 243-245.doi: 10.7506/spkx1002-6300-201003056

怀山药对小鼠学习记忆能力的影响

王丽娟^1,2，李杰²，张允²，王庆妍³

1.天津市食品生物技术重点实验室 2.天津商业大学生物技术与食品科学学院制药工程系 3.中南大学湘雅医学院护理学院

收稿日期:2009-03-25 出版日期:2010-02-01 发布日期:2010-12-29
通讯作者: 王丽娟 E-mail:wljuan@tjcu.edu.cn
基金资助:
天津市科委科技支撑计划重点项目(07ZCKFNC00200)

Effect of Dioscorea opposita on Learning and Memory Ability in Mice

WANG Li-juan1,2，LI Jie2，ZHANG Yun2，WANG Qing-yan3

1. Tianjin Key Laboratory of Food Biotechnology,Tianjin 300134, China；2. Department of Pharmaceutic Project, School of
Biotechnology and Food Science, Tianjin Commerce University, Tianjin 300134, China；3. School of Nursing, Xiangya School of
Medicine, Central South University, Changsha 410013, China

Received:2009-03-25 Online:2010-02-01 Published:2010-12-29
Contact: WANG Li-juan E-mail:wljuan@tjcu.edu.cn

摘要/Abstract

摘要：

以东莨菪碱和乙醇分别造成小鼠学习记忆获得障碍和记忆再现障碍，采用迷津法和跳台法观察并比较怀山药和吡拉西坦对小鼠学习记忆能力的影响。结果显示：怀山药(20g/kg 和30g/kg)及吡拉西坦(0.2g/kg)均可使小鼠逃避伤害刺激的反应速度加快，错误次数明显减少，遭电击时间缩短(与模型组比较，0.01 ＜ P ＜ 0.05)，两药的效果相近(P ＞ 0.05)。因此，怀山药对小鼠的学习和记忆障碍有改善作用，其作用机制有待进一步研究。

关键词: 怀山药, 吡拉西坦, 记忆获得障碍, 记忆再现障碍

Abstract:

Acquired dysmnesia and memory disorder models caused by scopolamine and alcohol, respectively, were used to compare the effects of Dioscorea opposita and piracetam on learning and memory function in mice by maze and step-down methods. Results indicated that aqueous extract of Dioscorea opposita could obviously improve learning and memory ability in mice. Compared with model group, groups treated with the extract at doses of 20 g /kg and 30 g/kg or piracetam exhibited fewer error times, longer latent period and shorter total time of electronic shock (0.01 ＜ P ＜ 0.05). While no significant difference between Dioscorea opposite-treated and piracetam-treated groups was observed (P ＞ 0.05). Therefore, Dioscorea opposita can obviously improve the ability of learning and memory in mice. However, further investigations on the related mechanisms are needed.

Key words: Dioscorea opposita, piracetam, acquired dysmnesia, memory disorder

中图分类号:

R285.5

王丽娟1,2，李杰2，张允2，王庆妍3. 怀山药对小鼠学习记忆能力的影响[J]. 食品科学, 2010, 31(3): 243-245.

WANG Li-juan1,2，LI Jie2，ZHANG Yun2，WANG Qing-yan3. Effect of Dioscorea opposita on Learning and Memory Ability in Mice[J]. FOOD SCIENCE, 2010, 31(3): 243-245.

[1]	任广跃，刘亚男，乔小全，段续，张乐道，罗登林. 基于变异系数权重法对怀山药干燥全粉品质的评价[J]. 食品科学, 2017, 38(1): 53-59.
[2]	任广跃，刘亚男，刘航，段续，张伟，俞喜娜. 响应面试验优化酶解辅助喷雾干燥制备怀山药粉工艺[J]. 食品科学, 2016, 37(6): 1-6.
[3]	任丽影，任广跃，杨晓童，张伟，段续，张乐道，朱文学. 涡流管制冷常压冷冻干燥怀山药技术分析[J]. 食品科学, 2015, 36(20): 7-12.
[4]	任广跃，任丽影，张伟，段续，罗磊，朱文学. 正交试验优化怀山药微波辅助真空冷冻干燥工艺[J]. 食品科学, 2015, 36(12): 12-16.
[5]	李瑜，郑磊，詹丽娟，司志敏. 微波烫漂对速冻怀山药品质的影响[J]. 食品科学, 2011, 32(17): 100-104.
[6]	任广跃，化春光，段续，朱文学. 鲜切怀山药片微波干燥特性及品质研究[J]. 食品科学, 2010, 31(22): 203-206.
[7]	盛玮1,2,3，薛建平2,3，谢笔钧1. 怀山药零余子提取物抗氧化活性的研究[J]. 食品科学, 2009, 30(3): 92-94.
[8]	朱军，宋卫东，杨宗渠，赵惠东，王允，全彦君，赵梅红，王万里. 怀山药辐射贮藏保鲜技术与应用研究[J]. 食品科学, 2009, 30(2 ): 272-274.
[9]	林雪玲, 程朝辉, 黄才欢, 李炎. 茶氨酸对小鼠学习记忆能力的影响[J]. 食品科学, 2004, 25(5): 171-173.

怀山药对小鼠学习记忆能力的影响

Effect of Dioscorea opposita on Learning and Memory Ability in Mice

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 9

编辑推荐

Metrics

本文评价