食品科学 ›› 2008, Vol. 29 ›› Issue (2): 59-63.

• 基础研究 • 上一篇    下一篇

胆固醇对红景天苷脂质体的制备及物化稳定性的影响

 范明辉, 许时婴   

  1. 江南大学食品学院; 江南大学食品学院 江苏无锡214122; 江苏无锡214122;
  • 出版日期:2008-02-15 发布日期:2011-08-24

Effects of Cholesterol on Salidroside Containing Liposomes Preparation and Physico-chemical Stability

 FAN  Ming-Hui, XU  Shi-Ying   

  1. School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
  • Online:2008-02-15 Published:2011-08-24

摘要: 本实验研究了胆固醇对红景天苷脂质体的作用,重点考查了包封率、Zeta电位、粒径大小、渗漏率和丙二醛(malondialdehyde,MDA)含量等指标。结果表明,红景天苷脂质体的包封率随着胆固醇嵌入量的增加呈现先增加后减小的趋势,但胆固醇的嵌入量对载量影响不大。4℃和30℃下贮藏一个月,没有任何胆固醇嵌入的脂质体渗漏率达到10%和15%,随着胆固醇嵌入量增加至1:5和1:2,脂质体的渗漏率分别下降为6%、5%和12%、10%。进一步增大胆固醇的嵌入量至1:1,其渗漏率又会明显增加。胆固醇和卵磷脂脂质量比1:2时,脂质体在4℃、30℃下贮藏一个月的物理稳定性最好。

关键词: 脂质体, 红景天苷, 胆固醇, 稳定性

Abstract: The effects of cholesterol on physicochemical characteristics of salidroside containing liposomes were investigated in present work. The results showed that the higher the cholesterol content is, the higher the encapsulating efficiency of liposomes until its mass is equal to that of lecithin. However, cholesterol content shows little effect on the salidroside loading. Experimental data indicated that the leakage percentage of no cholesterol-liposomes reach 10% and 15% at 4 ℃ and 30 ℃ respetively during one month period, in comparison with the liposomes incorporating cholesterol (1:5 and 1:2, W/W) with 6%, 5% and 12%, 10%, respectively. Liposomes incorporating cholesterol (1:1, W/W) resulted in the increasing leakage again. In conclusion, liposomes incorporating cholesterol (1:2, W/W) can show a better performance.

Key words: liposome, salidroside, cholesterol, stability