食品科学 ›› 2008, Vol. 29 ›› Issue (9): 598-600.

• 营养卫生 • 上一篇    下一篇

葡萄籽超微粉对高血脂金黄地鼠血浆NO、ET-1和C反应蛋白的影响

 郭金英, 李松彪, 刘开永, 侯玉泽, 崔国庭   

  1. 河南科技大学食品与生物工程学院;
  • 出版日期:2008-09-15 发布日期:2011-12-08

Effects of Ultrafine Grape Seed Powder on Levels of NO,ET-1 and C-reactive Protein in Plasma of Hyperlipemia Golden Hamsters

 GUO  Jin-Ying, LI  Song-Biao, LIU  Kai-Yong, HOU  Yu-Ze, CUI  Guo-Ting   

  1. College of Food and Bioengineering,Henan University of Science and Technology,Luoyang 471003,China
  • Online:2008-09-15 Published:2011-12-08

摘要: 探讨葡萄籽超微粉对高血脂诱发的动脉粥样硬化(AS)的预防作用及其机制。选用100只金黄地鼠,随机分成对照组、高血脂组、葡萄籽低剂量组、葡萄籽中剂量组和葡萄籽高剂量组。在试验的4w时间内,除对照组饲喂基础饲料外,其余各组均饲喂高脂饲料。第8w末,取金黄地鼠血浆进行NO、ET-1和C反应蛋白含量测定。结果表明,葡萄籽超微粉可提高高血脂金黄地鼠血浆NO水平、降低血浆ET-1的含量,降低C-反应蛋白含量。葡萄籽超微粉可改善血管内皮功能,对动脉粥样硬化的发生有一定的预防作用。

关键词: 葡萄籽超微粉, NO, ET-1, C反应蛋白

Abstract: To study the protective effect and mechanism of ultrafine grape seed powder on risk of hyperlipidemia, this experiment was conducted on 100 golden hamsters, which were divided into five groups, each of which contained 20 hamsters: control group, hyperlipidemia group, grape seed low dose group, middle dose group and high dose group. After completion of the trial, the plasma NO, ET-1 and C-reactive protein level were determined in golden hamsters. The results showed ultrafine grape seed powder increases the levels of NO of hyperlipidemia hamsters, and it also significantly decreases the contents of ET-1 and CRP of hyperlipidemia hamsters. Ultrafine grape seed powder can improve the blood vessel function and protect body from atherosclerosis occurrence.

Key words: ultrafine grape seed powder, NO, ET-1, C-reactive protein