关键词: 壳聚糖, 高血脂, 高血糖, 四氧嘧啶, 糖耐量, 免疫

Abstract: The purpose of this study was to investigate the chitosan’s effects on lowering hyperlipemia, lowering hyperglycemia and enhancing immunity .The effect of chotosan on hyperlipemia was investigated in male SD rats. There were respectively hyperlipemia control group, low dose group (83. 3mg/kg .bw),media dose group (166. 7mg/kg..bw) and high dose group (333. 3mg/kg .bw) .All groups were fed with chitosan 4 weeds.The results showed that:comparing with hyperlipemia control group me media and high dose group’s cholesterol level was lowered respectiuely 10. 5% (P<0. 01), 14. 2% (P<0.01); low, media and high dose group’s triglyceride lowered respectively 27. 5% (P<0.01), 18. 8% (p<0. 01) and 26. 1% (P<0. 01); low, media and high dose group’s high density lipoprotein cholesterol increased respectively 16. 5% (P<0.01), 32. 7% (p<0.001) and 50.4% (p<0.001) .The effects of chitosan on lowering hyperglycemia and enhancing imunity were investigated in Kurmingfemale mice.There were three dose groups: low dose group (166. 7 mg/kg..bw) I media dose group (333. 3 mg/kg. .bw) and high dose group (666. 7 mg/kg..bw) .There were the control group of the effect on enhancing immunity and the hyperglycemia model group of the effect on lowing hyperlycemia.All groups were fed with chitosan 3 weeks .The results of effect on lowering hyperlycemia indicated:colnparing with hyperglycemia control group, the low,media and high dose group’s blood sugar was lowered respectively 14. 1% (P<0. 05), 18.8% (p<0. 01) and 24. 9% (p<0. 01) .The blood sugar difference between 2 hour’s and 0 hour’s blood sugar after giving 50% glucose was lowered respectively 40. 0% (P<0. 001) , 30.1% (p<0.001) and 20. 6% (p<0.001) The results of effect on enhancing immunity Indicated: comparing with control group, the low, the media and high dose group’s carbon expurgation phagocytosis index was increased respectively 9.1% (P<0.01), 14. 8% (p<0.001) and 13. 4% (p<0.001); the low,media and high dose group’s delayed hypersen sitivity was increased respectively 82. 5% (P<0.01) , 82. 5% (p<0. 001) and 105. 3% (p<0. 001); the media and high group’s hemolysin was increased respectively 28. 1% (P<0.05), 28. 4% (p<0.05); the media dose group’s NK cell activity was increased 84. 3% (p<0. 05). These results indicated that the chitosan’s functions were affective signiticantly on lowering hyperlipemia, lowering hyperglycimia and enhanc ing immunity.

Key words: Chitosan Hyperlipemia Hyperglycemia Aoxsan Sugar tolerance Immunity