食品科学 ›› 2021, Vol. 42 ›› Issue (19): 379-387.doi: 10.7506/spkx1002-6630-20200925-315

• 专题论述 • 上一篇    

母乳低聚糖的体内代谢与体外合成研究进展

陈庆学,石丰毅,赵丽娜,梁胜男,Masumuzzanm MD,霍贵成,李柏良   

  1. (东北农业大学 乳品科学教育部重点实验室,黑龙江 哈尔滨 150036)
  • 发布日期:2021-11-12
  • 基金资助:
    黑龙江省“百千万”工程科技重大专项(2019ZX07801); 中国营养学会-飞鹤体质营养与健康研究基金项目(CNS-Feihe2020A37)

Recent Advances in in Vivo Metabolism and in Vitro Synthesis of Breast Milk Oligosaccharides

CHEN Qingxue, SHI Fengyi, ZHAO Lina, LIANG Shengnan, Masumuzzanm MD, HUO Guicheng, LI Bailiang   

  1. (Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150036, China)
  • Published:2021-11-12

摘要: 母乳低聚糖(human milk oligosaccharides,HMOs)是母乳中独特的营养成分,结构复杂,种类繁多,不同的HMOs可能具有不同的功能。本文在HMOs的个体差异性、结构多样性与功能活性方面介绍了HMOs的最新研究进展,重点阐述了HMOs在人体内的代谢途径以及体外的合成途径,最后阐述了HMOs在婴儿配方粉中的应用现状,提出了研究及应用中面临的问题。HMOs的应用是婴儿配方奶粉发展中的重大突破,缩小了配方奶粉喂养儿在肠道菌群组成、免疫功能以及认知等方面上与母乳喂养儿的差距。HMOs的深入研究为新型婴儿配方奶粉的开发提供理论依据。

关键词: 母乳低聚糖;结构多样性;代谢;合成;益生作用;应用现状

Abstract: Human milk oligosaccharides (HMOs) are unique nutrients in breast milk, which have complex and multifarious structures. Different HMOs may have different functions. In this article, we summarize the latest progress in understanding the individual difference, structural diversity and functional activity of HMOs. We put a special focus on the metabolic pathway in human body and the synthetic pathway in vitro of HMOs. Finally, we discuss the current status of the application of HMOs in infant formula and problems facing HMOs research and application. The application of HMOs in infant formula is a major breakthrough and it has great potential in narrowing the gap between formula-fed infants and breast-fed infants in intestinal flora composition, immune function and cognition capacity. In-depth studies of HMOs will offer the theoretical basis for the developement of new infant formula.

Key words: human milk oligosaccharides; structural diversity; metabolism; synthesis; probiotics; current applications

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