关键词: 表面增强拉曼光谱标签；标记技术；农药残留检测；新型拉曼报告分子；多残留检测

Abstract: Recently, surface enhanced Raman scattering (SERS) labels have attracted researchers’ attention owing to their high sensitivity, excellent multiplexing ability, insensitivity to photobleaching and good fidelity of molecular fingerprint, and have been successfully applied to sensing analysis and biological imaging. In this review, we summarize the principle of SERS label-based biosensors, and the state of the art in their application for rapid detection of pesticide residues. The focus of this review is on the design and fabrication of SERS labels and the current status of sensing systems based on different recognition elements. Meanwhile, the challenges in this field are discussed and possible solutions to them are proposed. This review is expect to help expand the application of SERS labels in the detection of pesticide residues and food safety.

Key words: surface enhanced Raman scattering tags; labeling technology; pesticide residue detection; novel Raman reporter molecules; multi-residue detection