食品科学 ›› 2025, Vol. 46 ›› Issue (1): 255-265.doi: 10.7506/spkx1002-6630-20231204-025

• 专题论述 • 上一篇    下一篇

功能性胆汁酸生物合成及应用研究进展

郑苗,常超,苏琪,蔡成岗,逯与运,赵敏洁,蔡海莺   

  1. (1.浙江科技学院生物与化学工程学院,浙江 杭州 310023;2.新加坡国立大学食品科学与工程系,新加坡 117542;3.浙江大学生物系统工程与食品科学学院,浙江 杭州 310058;4.美欣达集团有限公司,浙江 湖州 313002)
  • 出版日期:2025-01-15 发布日期:2024-12-30
  • 基金资助:
    国家自然科学基金面上项目(32172214;31972079); 浙江省自然科学基金一般项目(LGF20E030001;LY18C200006);湖州市重点研发计划项目(2022ZD2057)

Research Progress on the Biosynthesis and Applications of Functional Bile Acids

ZHENG Miao, CHANG Chao, SU Qi, CAI Chenggang, LU Yuyun, ZHAO Minjie, CAI Haiying   

  1. (1. School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China; 2. Department of Food Science and Engineering, National University of Singapore, Singapore 117542, Singapore; 3. College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China; 4. Mizuda Group Co. Ltd., Huzhou 313002, China)
  • Online:2025-01-15 Published:2024-12-30

摘要: 胆汁酸(bile acid,BA)作为胆汁重要的两性固醇类物质,可通过与受体、肠道菌群的相互作用调节糖脂代谢及稳态、肠道微生态、肠道屏障、炎症、免疫系统和神经系统等生理功能,影响机体代谢和营养健康。本文综述主要新型功能性BA的合成通路,系统总结主要功能性BA的功能活性、化学合成和生物转化研究进展。此外,归纳新型BA(异脱氧胆酸、异石胆酸、异别脱氧胆酸、异别石胆酸)功能性研究,以及新型BA生物转化酶的微生物来源、催化性质及其应用于BA合成的潜力。展望功能性BA在食品和医药等领域的应用潜力,为新型功能性BA的合成转化及综合应用提供一定参考。

关键词: 胆汁酸;功能性;生物转化;羟基类固醇脱氢酶;应用

Abstract: Bile acid (BA), as an important amphoteric sterol in bile, can regulate glucose and lipid metabolism and homeostasis, intestinal microecology, the intestinal barrier, inflammation, the immune system and the nervous system and other physiological functions through interaction with receptors and the intestinal flora, and consequently affect metabolism and nutritional health in the body. In this article, the synthesis pathways of the major new functional BAs are reviewed, and recent progress in research on their functional activity, chemical synthesis and biotransformation is systematically summarized. In addition, this article summarizes the functional studies of selected novel BAs (isodeoxycholic acid, isolithocholic acid (isoLCA), isoallodeoxycholic acid, and isoallolithocholic acid), as well as the microbial sources and catalytic properties of bioconvertases associated with the novel BAs and their potential for application in BA synthesis. Moreover, this article provides an outlook on the application potential of functional BAs in the fields of food and medicine, which provide a reference for the synthesis and transformation of new functional BAs and their comprehensive applications.

Key words: bile acids; functionality; biotransformation; hydroxysteroid dehydrogenase; application

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