鼠李糖乳酪杆菌HM126调节小鼠肠道菌群及代谢物缓解过敏性鼻炎

doi:10.7506/spkx1002-6630-20250102-012

食品科学 ›› 2025, Vol. 46 ›› Issue (14): 157-155.doi: 10.7506/spkx1002-6630-20250102-012

• 营养卫生 • 上一篇

鼠李糖乳酪杆菌HM126调节小鼠肠道菌群及代谢物缓解过敏性鼻炎

袁雪萍，赵育瑾，李先平，张宇，李肖静，姚春宇，唐蜜，刘璐，赵军英，乔为仓，高子晴，陈历俊

（1.大连工业大学生物工程学院，辽宁?大连 116034；2.北京三元食品股份有限公司，国家母婴乳品健康工程技术研究中心，北京市乳品工程技术研究中心，母乳研究技术创新中心，北京 100163；3.东北农业大学食品学院，黑龙江?哈尔滨 150030）

发布日期:2025-06-20
基金资助:
国家自然科学基金面上项目（32072191）；中央引导地方科技发展专项（桂ZY22096025）；北京市科技计划课题（Z221100006422012）；首农食品集团自立科技项目

Lacticaseibacillus rhamnosus HM126 Alleviates Allergic Rhinitis by Modulating the Intestinal Flora and Metabolites in Mice

YUAN Xueping, ZHAO Yujin, LI Xianping, ZHANG Yu, LI Xiaojing, YAO Chunyu, TANG Mi, LIU Lu, ZHAO Junying, QIAO Weicang, GAO Ziqing, CHEN Lijun

(1. School of Biological Engineering, Dalian Polytechnic University, Dalian 116034, China; 2. National Engineering Research Center of Dairy Health for Maternal and Child, Beijing Engineering Research Center of Dairy, Beijing Technical Innovation Center of Human Milk Research, Beijing Sanyuan Foods Co. Ltd., Beijing 100163, China; 3. College of Food Science, Northeast Agricultural University, Harbin 150030, China)

Published:2025-06-20

摘要/Abstract

摘要： 本实验通过给予过敏性鼻炎（allergic rhinitis，AR）小鼠鼠李糖乳酪杆菌（Lacticaseibacillus rhamnosus）HM126研究其对AR的预防和缓解作用。利用卵清蛋白建立AR小鼠模型，研究L. rhamnosus HM126干预后AR症状的改善状况，并采用16S rRNA测序和非靶代谢分析肠道微生物群组成及代谢物差异。结果显示，AR小鼠经L. rhamnosus HM126干预后鼻部症状显著减轻，鼻功能恢复正常。肠道菌群与代谢组相关性分析发现，该菌可以通过调节肠道菌群的相对丰度，促使代谢物奎宁酸、氨苯砜、来普霉素B、酮洛芬、18α-甘草次酸、积雪草酸增加，从而缓解AR症状。结果表明，L. rhamnosus HM126可能通过调节小鼠肠道微生物群失调及产生免疫调节物质改善过敏性炎症反应，本研究可为益生菌改善AR提供理论支持。

关键词: 过敏性鼻炎；益生菌；鼠李糖乳酪杆菌；非靶代谢；肠道菌群

Abstract: We investigated the role of Lacticaseibacillus rhamnosus HM126 in the prevention and alleviation of ovalbumin-induced allergic rhinitis (AR) in mice. We also analyzed the composition of the gut microbiota and the differences in metabolite profile using 16S rRNA gene sequencing and untargeted metabolomics, respectively. The results showed that the nasal symptoms of AR mice were significantly reduced and the nasal function was restored to normal after intervention with L. rhamnosus HM126. The correlation analysis between the gut flora and metabolome revealed that this strain could alleviate AR symptoms by modulating the relative abundance of the gut flora and inducing an increase in metabolites such as quinic acid, leptomycin b, ketoprofen, 18 alpha-glycyrrhetinic acid, and asiatic acid. This study suggested that L. rhamnosus HM126 can ameliorate allergic inflammatory response by regulating gut microbiota dysbiosis and producing immunomodulatory substances in mice, providing theoretical support for the alleviation of AR by probiotics.

Key words: allergic rhinitis; probiotics; Lacticaseibacillus rhamnosus; untargeted metabolomics; gut flora

中图分类号:

R765.21

袁雪萍，赵育瑾，李先平，张宇，李肖静，姚春宇，唐蜜，刘璐，赵军英，乔为仓，高子晴，陈历俊. 鼠李糖乳酪杆菌HM126调节小鼠肠道菌群及代谢物缓解过敏性鼻炎[J]. 食品科学, 2025, 46(14): 157-155.

YUAN Xueping, ZHAO Yujin, LI Xianping, ZHANG Yu, LI Xiaojing, YAO Chunyu, TANG Mi, LIU Lu, ZHAO Junying, QIAO Weicang, GAO Ziqing, CHEN Lijun. Lacticaseibacillus rhamnosus HM126 Alleviates Allergic Rhinitis by Modulating the Intestinal Flora and Metabolites in Mice[J]. FOOD SCIENCE, 2025, 46(14): 157-155.

鼠李糖乳酪杆菌HM126调节小鼠肠道菌群及代谢物缓解过敏性鼻炎

Lacticaseibacillus rhamnosus HM126 Alleviates Allergic Rhinitis by Modulating the Intestinal Flora and Metabolites in Mice

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