食品科学 ›› 2010, Vol. 31 ›› Issue (20): 137-140.doi: 10.7506/spkx1002-6630-201020028

• 工艺技术 • 上一篇    下一篇

壳聚糖-海藻酸钠叶绿素亚铁微胶囊的制备及缓释性能研究

孟庆廷,陈万东   

  1. 济宁学院化学与化工系
  • 收稿日期:2010-01-11 修回日期:2010-09-10 出版日期:2010-10-25 发布日期:2010-12-29
  • 通讯作者: 孟庆廷 E-mail:mqingting@163.com

Preparation and Sustained-release Performance of Chitosan-Sodium Alginate Sodium-Sodium Ferrous Chlorophyllin Microcapsules

MENG Qing-ting,CHEN Wan-dong   

  1. Department of Chemistry and Chemical Engineering, University of Jining, Jining 273155, China
  • Received:2010-01-11 Revised:2010-09-10 Online:2010-10-25 Published:2010-12-29
  • Contact: MENG Qing-ting E-mail:mqingting@163.com

摘要:

用壳聚糖- 海藻酸钠微囊技术制备一系列叶绿素亚铁微胶囊,以包封率和载药量作为制备工艺优化指标,通过正交试验得出最优方案。考察微胶囊在模拟胃液和模拟肠液中的控制释放效果。结果显示,制备该微胶囊的最优方案为海藻酸钠15mg/mL、壳聚糖4mg/mL、氯化钙20mg/mL、芯材与海藻酸钠的质量比1:4。所得胶囊在模拟胃液和模拟肠液中缓释性能良好。

关键词: 壳聚糖-海藻酸钠叶绿素亚铁微胶囊, 载药量, 包封率, 缓释

Abstract:

Sodium ferrous chlorophyllin was microencapsulated into chitosan-sodium alginate micropheres for the purpose of sustained release. The microencapsulation process for sodium ferrous chlorophyllin was optimized using orthogonal array design for achieving both higher entrapment efficiency and drug loading. Meanwhile, the sustained release of the prepared microcapsules in mimic gastric and intestinal environments was observed. The optimal microcapsule formula was found to be composed of 15 mg/mL sodium alginate, 4 mg/mL chitosan and 20 mg/L CaCl2 with a core material/wall material ratio of 1:4. The microcapsules obtained using this formula displayed good sustained-release performance in both mimic environments.

Key words: chitosan-sodium alginate sodium-sodium ferrous chlorophyllin microcapsules, drug loading, entrapment efficiency, sustained release

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