Hepatoprotective Function of Germanium-rich Barley Seedling in Mice with Acute Hepatic Injury

doi:10.7506/spkx1002-6300-200921087

FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (21 ): 371-373.doi: 10.7506/spkx1002-6300-200921087

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Hepatoprotective Function of Germanium-rich Barley Seedling in Mice with Acute Hepatic Injury

DU Rong1，WANG Xiao-jie1,*，RUAN Xin2，LIU Xin-sheng3，QU Yan-qing3，YANG Li-hong1，XIAO Yan-yan1，GAO Hong-yue1

1. College of Life Science, Ludong University, Yantai 264025, China；2. Yantai Entry-Exit Inspection and Quarantine Bureau,
Yantai 264000,China；3. College of Hospital, Ludong University, Yantai 264025, China

Received:2009-06-28 Online:2009-11-01 Published:2010-12-29
Contact: WANG Xiao-jie E-mail:wxj10304@126.com

Abstract

Abstract:

Objective: To investigate hepatoprotective effect of germanium-rich barley seedling (GRBS) in mice with acute hepatic injury induced by CCl4. Methods: Mice model with acute hepatic injury was established through induction of CCl4. The mice with acute hepatic injury were orally administered GRBS at different doses (low, medium and high-doses). ALT activity in serum and immune organs index were determined and pathological changes of livers were examined to evaluate the hepatoprotective effect of GRBS. Results: GRBS at three doses significantly inhibited ALT activity in serum (P < 0.05, P < 0.01) and promoted the recovery of hepatic tissue injury, which was in a dose-dependent mode. Moreover, GRBS also obviously improved liver index (P < 0.01) and spleen index (P < 0.01, P < 0.05). Conclusion: GRBS has hepatoprotective function for mice with acute hepatic injury induced by CCl4.

Key words: germanium-rich barley seedling, CCl4, acute hepatic injury, mice

CLC Number:

TS210.1

DU Rong1，WANG Xiao-jie1,*，RUAN Xin2，LIU Xin-sheng3，QU Yan-qing3，YANG Li-hong1，XIAO Yan-yan1，GAO Hong-yue1. Hepatoprotective Function of Germanium-rich Barley Seedling in Mice with Acute Hepatic Injury[J]. FOOD SCIENCE, 2009, 30(21 ): 371-373.

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Hepatoprotective Function of Germanium-rich Barley Seedling in Mice with Acute Hepatic Injury

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