Protective Effect of Soybean Polypeptides on Acute Liver Injury in Mice

doi:10.7506/spkx1002-6300-200921089

FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (21 ): 377-379.doi: 10.7506/spkx1002-6300-200921089

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Protective Effect of Soybean Polypeptides on Acute Liver Injury in Mice

QI Ying-xin1，MENG Jun2，CAO Bai-ying1，CHANG You-quan1，SU Wei1

1. College of Food Engineering, Jilin Teachers’Institute of Engineering and Technology, Changchun 130052, China ；
2. Tonghua Food and Drug Administration of Jilin, Tonghua 134000, China

Received:2009-07-01 Online:2009-11-01 Published:2010-12-29
Contact: QI Ying-xin E-mail:qyxlclhb@163.com

Abstract

Abstract:

Mice with acute liver injury were modeled through CCl4 induction and orally administered with soybean polypeptides at doses of 3, 1.8 and 0.6 g/kg·d for 30 d, respectively. Effects of soybean polypeptides on glutamic-oxaloacetic transminase (GOT), glutamic-pyruvic transminase (GPT) and alkaline phosphataes (ALP) in serum and triglyceride (TG), total cholesterol (TC), malondialdehye (MDA) and glutathione peroxidase (GSH) levels in liver were investigated. Results indicated that CCl4- induced mice model with liver injury was successfully established. Soybean polypeptides significantly decreased the levels of GOT, GPT and AST in serum and TG, TC and MDA in liver, and obviously increased the level of GSH in liver in a dosedependent manner. Therefore, soybean polypeptides have an excellent protective capability against acute liver injury in mice induced by CCl4.

Key words: soybean polypeptides, liver injury, GPT, GOT, ALP, MDA, GSH

CLC Number:

TS214

QI Ying-xin1，MENG Jun2，CAO Bai-ying1，CHANG You-quan1，SU Wei1. Protective Effect of Soybean Polypeptides on Acute Liver Injury in Mice[J]. FOOD SCIENCE, 2009, 30(21 ): 377-379.

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Protective Effect of Soybean Polypeptides on Acute Liver Injury in Mice

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