Abstract:

Objectives: To explore the inhibitive effect of different dosages of soybean isoflavone on benign prostatic hyperplasia of rats and the relationship between the antioxidation of soybean isoflavone and the inhibition of benign prostatic hyperplasia. Methods: The prostate hyperplasia of rats was induced by subcutaneous injection with testosterone propionate, and the changes of prostate wet weight, prostatic index, total antioxidation capacity (TAOC), activities of catalase（CAT）, superoxide dismutase（SOD）, glutathione peroxidase（GSH）, and level of maleic dialdehyde（MDA）of prostate tissue in the control, the model and the soybean isoflavone (low, moderate and high doses, respectively) groups were observed. Results: The prostate wet weight, prostatic index and MDA level in all soybean isoflavone groups are significantly lower than those in the model group (p ＜ 0.05), while CAT, TAOC, SOD and GSH in all soybean isoflavone groups are significantly higher than those in the model group, especially the effect of moderate dose is the most obvious. Conclusion: Soybean isoflavone may effectively inhibit the development of prostate hyperplasia and promote the antioxidation of rats. Therefore, soybean isoflavone may serve as the supplementary therapy and prevention for benign prostatic hyperplasia.

Key words: soybean isoflavone, prostatic hyperplasia, antioxidation