Abstract:

Different doses (0.2, 0.4 and 0.8 g/kg bw) of crude polysaccharide extracted from submerged fermentation liquid Pleurotus cirtinopileatus was administered to S180 tumor-bearing mice by gavage to study its antitumor activity in vivo. The tumor inhibition rates by the three doses were 9.62%, 35.84% and 40.93%, respectively. Meanwhile, both the thymus index and the spleen index of S180 tumor-bearing mice were elevated. So we conclude that the polysaccharide from submerged fermentation liquid of Pleurotus cirtinopileatus has antitumor activity.

Key words: Pleurotus cirtinopileatu, submerged fermentation liquid, polysaccharide, antitumor