Abstract:

Objective: To study the effect of apple polyphenol on lipid metabolism in mice. Methods: Totally 50 mice were randomly divided into 5 groups. Four groups were fed with high fat diet except for the normal control group. The normal control and obesity control groups were administrated with normal saline, and other three groups were administered with apple polyphenol at the dosages of 3.8, 7.6 mg/(kg bw·d) and 11.4 mg/(kg bw·d), respectively. Four weeks later, the mice were sacrificed to assay body weights, contents of serum total triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) malondialdehyde (MDA), activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), hepatic lipase (HL) and lipoprotein lipase (LPL). Results: Apple polyphenol could obviously reduce the body weights of mice, the contents of TG, TC, LDL-C and MDA, and atherosclerosis index (AI). In contrast, it could also improve HDL-C and the activities of SOD, GSH-PX, HL and LPL in serum. Conclusion: Apple polyphenol has the function in reducing blood lipid through adjusting lipid metabolism of mice to prevent atherosclerosis diseases.

Key words: apple polyphenol, blood lipid, lipid peroxidation, lipid metabolism, atherosclerosis disease