FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (11): 298-302.doi: 10.7506/spkx1002-6630-201011065

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Research Advances in Tetrodotoxin and Its Fermentation

GU Jiang-wen1,XU Shan-liang2,*,YAN Fu-yun1,CHEN Xuan-xiong1   

  1. 1.Key Laboratory of Marine Biotechnology of Zhejiang, Ningbo University, Ningbo 315211, China ;
    2. Key Laboratory of Applied Marine Biotechnology, Ministry of Education, Ningbo University, Ningbo 315211, China
  • Received:2009-10-19 Online:2010-06-01 Published:2010-12-29
  • Contact: XU Shan-liang2 E-mail:xushanliang@nbu.edu.cn

Abstract:

Tetrodotoxin (TTX) is a highly toxic amino hydrogenated quinazoline compound in puffer fish. TTX is one of the most lethal biological toxins. It is also a powerful anesthetic and detoxification agent. Therefore, further studies on preparation technology and high-yield strategies of TTX for extending its medicinal values are being conducted according to the understanding of its generation pathways and TTX-producing strains. In this paper, basic characteristics of TTX including the origin, physical and chemical properties, biological activity are reviewed. In addition, current hot research direction and corresponding issues such as TTX-producing strain and its fermentation are also comprehensively analyzed.

Key words: puffer fish, tetrodotoxin, TTX-producing strain, fermentation

CLC Number: