Abstract:

Objective: To study the effects of casein phosphopeptides (CPPs), high-calcium diet and their combination on uric acid (UA), total cholesterol (TC), xanthine oxidase (XOD) and adenosine deaminase (ADA) in the serum and XOD and ADA in the liver of hyperuricemic rats. Methods: Hyperuricemic model rats were induced by intragastric administration with adenine (100 mg/(kg bw·d)) and ethambutol (250 mg/(kg bw·d)) for 3 weeks. The model rats were then treated with foods containing CPPs, high-calcium diet and their combination for 28 days. After intervention for 28 days, UA, TC, XOD and ADA in serum and XOD and ADA in liver were determined. Results: Serum uric acid level of rats induced by intragastric administration was significantly higher than that in the control group before intervention. Compared with the model rats, each intervention group exhibited an obvious decrease in UA and TC levels. The XOD activities in all the intervention groups were all lower than those in the liver of the model group, and the ADA activities in all the intervention groups were lower than those in both the serum and liver of the model groups, especially in high-calcium diet and their combination intervention groups (P < 0.05). Conclusion: CPPs and high-calcium diet exhibit a high potential to decrease uric acid level.

Key words: hyperuricemic, casein phosphopeptides, calcium, uric acid, total cholesterol