Inhibitory Effect of Different Polarity Fractions of Ethanol Extract from Oat on Vascular Smooth Muscle Cell Proliferation

doi:10.7506/spkx1002-6630-201021076

FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (21): 335-339.doi: 10.7506/spkx1002-6630-201021076

• Nutrition & Hygiene • Previous Articles Next Articles

Inhibitory Effect of Different Polarity Fractions of Ethanol Extract from Oat on Vascular Smooth Muscle Cell Proliferation

HUANG Chen，JI Bao-ping*，YANG Pei-ying，ZHOU Feng，WU Wei，CAI Sheng-bao

College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China

Received:2010-04-19 Revised:2010-07-30 Online:2010-11-15 Published:2010-12-29
Contact: JI Bao-ping E-mail:jbp@cau.edu.cn

Abstract

Abstract:

The ethanol extract from oat was fractionated with different polarity solvents (n-hexane, ethyl acetate, 1-butanol and water), and the four fractions obtained were assessed for their abilities to scavenge DPPH free radicals, inhibit the proliferation of vascular smooth muscle cells (VSMC) and promote the release of NO from VSMC in vitro. Among these four fractions, the ethyl acetate soluble fraction had the most prominent DPPH free radical scavenging ability, with an EC50 of (2.5 ± 0.4)mg/mL. Meanwhile, this fraction could remarkably inhibit the proliferation of VSMC and elevate the NO producing ability. The preliminary HPLC analysis indicated that this fraction mainly contained three kinds of avenanthramide, Bc, Bp and Bf.

Key words: ethanol extract from oat, vascular smooth muscle cell, inhibition of proliferation, NO

CLC Number:

TS210.1

HUANG Chen，JI Bao-ping*，YANG Pei-ying，ZHOU Feng，WU Wei，CAI Sheng-bao. Inhibitory Effect of Different Polarity Fractions of Ethanol Extract from Oat on Vascular Smooth Muscle Cell Proliferation[J]. FOOD SCIENCE, 2010, 31(21): 335-339.

[1]	WANG Feng, XIAO Chuxiang, LIU Shuzhen, WANG Fengwu. Extraction of Flavonoids from Durian Seeds and Its Antioxidant and Anti-aging Effects in Caenorhabditis elegans [J]. FOOD SCIENCE, 2021, 42(9): 123-129.
[2]	YIN Hongjie, JU Huapeng, ZHONG Limin, SUN Na, LIN Songyi. Biological Activity and Structural Characterization of Riboflavin-Binding Peptide [J]. FOOD SCIENCE, 2021, 42(9): 137-144.
[3]	TIAN Xiaoling, WANG Xiaoxi. Current Status of Mechanochemistry and Its Application Prospects in Wheat Milling [J]. FOOD SCIENCE, 2021, 42(9): 275-282.
[4]	LI Caiyun, LI Jie, YAN Shoulei, WANG Qingzhang. Progress in Research on the Mechanism of Enzymatic Browning in Fruits and Vegetables [J]. FOOD SCIENCE, 2021, 42(9): 283-292.
[5]	SHI Yuanyue, YANG Yufan, KONG Baohua, WANG Hao. Progress in the Encapsulation of Natural Phenolic Compounds by Electrospinning [J]. FOOD SCIENCE, 2021, 42(9): 319-327.
[6]	LUO Xiangxiang, ZHOU Yingqin, HUANG Jingjing, XIE Ningning, YAN Yan, CHEN Xiao’e. Inhibitory Mechanism of Garlic Disulphides on the Formation of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in Deep-Fried Chicken Breast [J]. FOOD SCIENCE, 2021, 42(9): 31-38.
[7]	ZHU Min, JIN Lin, ZHAO Hao’an, WANG Qian, ZHANG Jinjin, YANG Erlin, CAO Wei. Gastroprotective Effect of Amorpha fruticosa L. Honey against Ethanol-Induced Acute Gastric Ulcer in Mice [J]. FOOD SCIENCE, 2021, 42(9): 77-84.
[8]	DONG Ye, ZHANG Yiqi,, YAO Hongzheng, HE Guangxi, DAI Zhiyuan,. Effect of Different Pretreatments on the Free Amino Acids and Volatile Components of Bighead Carp Bone Protein Hydrolysates [J]. FOOD SCIENCE, 2021, 42(8): 179-185.
[9]	XIANG Ting, XIA Chen, LIU Jianhua, WANG Chaoran, SHEN Jianfu. Separation, Structural Identification and Anti-tumor Effects of New Compounds from Cordyceps militaris [J]. FOOD SCIENCE, 2021, 42(8): 235-242.
[10]	SUN Zongbao, Wang Tianzhen, Zou Xiaobo, LIU Yuan, Liang Liming, LI Junkui, Liu Xiaoyu. Discrimination between Raw and Restructured Beef Steak Using Hyperspectral and Ultrasound Imaging [J]. FOOD SCIENCE, 2021, 42(8): 257-263.
[11]	WANG Suli, GUO Zhenfu, GENG Lili. Liquid Phase Microextraction with Deep Eutectic Solvent Combined with High Performance Liquid Chromatography for Determination of New Neonicotinoid Insecticide Residues in Edible Oil [J]. FOOD SCIENCE, 2021, 42(8): 277-282.
[12]	WANG Yue, SHAO Lin, LI Qianxue, YI Le, QU Han, WANG Hongli, SHEN Minghao. Aptamer Combined with Quantum Dot for Simultaneous Detection of Staphylococcus aureus and Escherichia coli O157:H7 [J]. FOOD SCIENCE, 2021, 42(8): 305-312.
[13]	TAN Guiliang, PAN Ziqiang, ZHANG Shiwei, HU Min, FENG Ronghu, YANG Maoxun. Fluorescent Microspheres Competitive Immunochromatography Combined with Naked Eye Reading for Rapid and Semi-quantitative Detection of Sibutramine in Food Supplements [J]. FOOD SCIENCE, 2021, 42(8): 313-318.
[14]	LÜ Bowen, GENG Xiaoqian, ZHANG Yueshu, YU Ze, LI Chunqiang, SHAO Junhua. Effect of Pyrophosphate on the Dissociation of Natural and Oxidized Actomyosin [J]. FOOD SCIENCE, 2021, 42(8): 10-16.
[15]	ZHAO Jingsong, WANG Yusheng, LI Tianhao, ZHAO Wenqing, CHEN Haihua. Construction and Properties of Polyglycerol Monolaurate-Oleic Acid Microemulsion System [J]. FOOD SCIENCE, 2021, 42(8): 81-89.

Inhibitory Effect of Different Polarity Fractions of Ethanol Extract from Oat on Vascular Smooth Muscle Cell Proliferation

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments