Protective Effect of Liquiritin against Cerebral Ischemia/Reperfusion Inflammatory Injury in Mice

doi:10.7506/spkx1002-6630-201023078

FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (23): 353-355.doi: 10.7506/spkx1002-6630-201023078

• Nutrition & Hygiene • Previous Articles Next Articles

Protective Effect of Liquiritin against Cerebral Ischemia/Reperfusion Inflammatory Injury in Mice

SUN Ya-xuan1,2，LIU Ting3，DAI Xue-ling1，GAO Zhao-lan1，WEI Rong1，ZHENG Qiu-sheng3

1. College of Appllied Sciences and Humanities, Beijing Union University, Beijing 100191, China；
2. Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, China；
3. Department of Pharmacy, Shihezi University, Shihezi 832003, China

Received:2010-03-23 Online:2010-12-15 Published:2010-12-29
Contact: SUN Ya-xuan E-mail:sunxx@ygi.edu.cn

Abstract

Abstract:

Objective: To investigate the protective effect and mechanism of liquiritin against cerebral ischemia/reperfusion inflammatory injury in mice. Methods: ICR mice were randomly divided into sham group, model group, positive control group (intraperitoneally administered edaravone, 3 mg/(kg bw·d)), and liquiritin groups (intragastrically administered, 40, 20 mg/(kg bw·d) and 10 mg/(kg bw·d)). Focal cerebral ischemia/reperfusion models were set up by using intraluminal filament method. After cerebral ischemia for 2 h and subsequent reperfusion for 22 h, histopathology changes were monitored, and the activity of MPO and the expression of intercellular adhesion molecule-1(ICAM-1) in brain tissue were measured. Results: Compared with the model group, liquiritin noticeably decreased the activity of MPO and the expression of ICAM-1. Conclusion: Liquiritin has protective effects against cerebral ischemic/reperfusion inflammatory injury.

Key words: liquiritin, cerebral ischemia/reperfusion, inflammatory injury, MPO, intercellular adhesion molecule-1

CLC Number:

R931.71

SUN Ya-xuan1,2，LIU Ting3，DAI Xue-ling1，GAO Zhao-lan1，WEI Rong1，ZHENG Qiu-sheng3. Protective Effect of Liquiritin against Cerebral Ischemia/Reperfusion Inflammatory Injury in Mice[J]. FOOD SCIENCE, 2010, 31(23): 353-355.

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Protective Effect of Liquiritin against Cerebral Ischemia/Reperfusion Inflammatory Injury in Mice

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