Abstract: The objective of this study was to observe the effect of egg white oligopeptide and the four blind sides on memory enhancing in mice. Based on SMG-2 water maze, the length of incubation period in blind-sideⅠ, Ⅱ, Ⅲ and Ⅳ in water maze of mice administered intragastrically with high F value oligopeptide from egg white were measured. The results showed that the mice treated with high F value oligopeptide showed significant differences from the control group. Significance test of differences among latent times after a certain time of administration indicated that latent times in mice after 60 days of administration significantly differed from those after fewer days (30, 40 and 50). And mice in blind-side Ⅰ, Ⅱ, Ⅲ and Ⅳ area had a timedependent incubation period upon training, implying that the more complex the maze was, the more intense time-dependent was. While evaluating the memory enhancing ability of egg white oligopeptide, it is better to analyze the incubation period of mice in blind-sideⅠand Ⅱ.

Key words: memory enhancement, water maze, blind-side, test time