Hypoglycemic Effect of Total Flavonoids Extract from Chaya Leaves in Alloxan-induced Diabetic Rats

doi:10.7506/spkx1002-6630-201105064

FOOD SCIENCE ›› 2011, Vol. 32 ›› Issue (5 ): 291-295.doi: 10.7506/spkx1002-6630-201105064

• Nutrition & Hygiene • Previous Articles Next Articles

Hypoglycemic Effect of Total Flavonoids Extract from Chaya Leaves in Alloxan-induced Diabetic Rats

ZHOU Cai-qiong，YOU Qiao-ning

Chongqing Special Food Programme and Technology Research Center, College of Food Science, Southwest University,
Chongqing 400715, China

Received:2010-06-20 Revised:2011-01-24 Online:2011-03-15 Published:2011-03-03
Contact: ZHOU Cai-qiong E-mail:zhoucaiqiong@swu.edu.cn

Abstract

Abstract: Purpose: To investigate the hypoglycemic effect of Chaya leaf total flavonoids extract (CLTFE) on alloxan (ALX)-induced diabetic rats. Methods: A total of 44 rats were randomly divided into normal control group (normal feed), model control group (ALX), drug treatment control group (ALX + Metformin hydrochloride) and CLTFE treatment groups (ALX + CLTFE at the high and low dosages of 0.21 g/kg and 0.14 g/kg, respectively). The serum levels of fasting blood glucose (FPG), oral glucose tolerance test (OGTT), glycosylated serum protein (GSP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) of rats in each group were determined after consecutive feeding for 28 days. Results: CLTFE significantly reduced the serum levels of FPG, OGTT, GSP, ALT, AST, BUN, TG and LDL-C (P＜0.05) in ALX-induced rats, and significantly increased the serum level of HDL-C and body weight of ALX-induced rats (P＜0.05). Conclusion: CLTFE can improve the situation of weight loss in diabetic rats, and have auxiliary hypoglycemic effect in alloxan-induced diabetic rats.

Key words: new food resource, Chaya leafs, total flavonoids, hypoglycemic effect

CLC Number:

R587.1

ZHOU Cai-qiong，YOU Qiao-ning. Hypoglycemic Effect of Total Flavonoids Extract from Chaya Leaves in Alloxan-induced Diabetic Rats[J]. FOOD SCIENCE, 2011, 32(5 ): 291-295.

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Hypoglycemic Effect of Total Flavonoids Extract from Chaya Leaves in Alloxan-induced Diabetic Rats

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