Abstract: Objective: To explore the protective effect of chondroitin sulfate from sea cucumber against alcohol-induced gastric ulcer in rats. Methods: Thirty-two rats were randomized into 4 groups including model group, low dose group, medium dose group and high dose group. At the end of the 3rd day of administration, the ulcer bleeding, ulcer index, incidence rate and histological characteristics of each rat were evaluated. Results: Compared with the model group, the administration of chondroitin sulfate at low, medium and high doses could reduce bleeding area and ulcer index. Conclusion: Chondroitin sulfate from sea cucumber can significantly reduce bleeding area and ulcer index so that it has excellent preventive function of gastric ulcer.

Key words: chondroitin sulfate from sea cucumber, alcohol-induced gastric ulcer, ulcer index, rat