Anti-tumor Components from Fermentation Products of Fungus Salcoli6 Derived from Salicornia herbacea

doi:10.7506/spkx1002-6630-201121002

Abstract

Abstract: The anti-tumor components were isolated and identified from fermentation products of fungus Salcoli6 derived from Salicornia herbacea by bioassay-guided method. Seven compounds were isolated sequentially by solvent extraction, silica gel column chromatography and preparative HPLC. Their structures were identified as cladosporin (1), isocladosporin (2), naphthalenone (3), 2-acetyl-quinazoline (4), 3-hydroxy-2-methyl-chromen (5), 3-methylisobenzofuran (6) and p-hydroxyphenyl-acetic acid (7) by physicochemical properties and spectral analysis, respectively. The anti-tumor activity of the compounds was evaluated by SRB method. Compounds 3, 4 and 7 revealed cytotoxicity with IC50 of 12, 24 and 6μg/mL against p388 cell line, respectively; however, other compounds were inactive.

Key words: Salicornia herbacea-derived fungus, fermentation product, anti-tumor activity

CLC Number:

TS201.2

ZHAO Yu-hui，YANG Hai-yan，XIN Zhi-hong. Anti-tumor Components from Fermentation Products of Fungus Salcoli6 Derived from Salicornia herbacea[J]. FOOD SCIENCE, 2011, 32(21): 6-11.

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Anti-tumor Components from Fermentation Products of Fungus Salcoli6 Derived from Salicornia herbacea

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