Protective Effect of Whey Protein and Polypeptide from Small Black Soybean on Acute Liver Injury in Mice

doi:10.7506/spkx1002-6630-201305049

Abstract

Abstract: Objective: To explore the protective effect of whey protein and polypeptide from small black soybean on CCl4-induced acute hepatic injury in mice. Methods: The protein and polypeptide were added to mice feed at the dose of 6 g/(kg?d) and 2 g/(kg?d), respectively, which were fed to the mice for 30 d. Mouse model of acute hepatic injury was established by intragastric feeding with 1% CCl4 (80 mg/kg). The mice were sacrificed at the end of the experiment. The effect of the protein and polypeptide on serum AST and ALT activities and liver GSH, TG and MDA contents was observed. Results: Compared with the model group, whey protein and polypeptide could decrease ALT activity in mice in serum and TG and MDA levels in mouse liver significantly (P＜0.01), and increase GSH content in mouse liver (P＜0.01). The polypeptide at high dosage revealed the most obvious effect. Conclusion: Whey protein and polypeptide from small black soybean have protective capability against acute liver injury in mice induced by CCl4.

Key words: small black soybean, whey protein, whey polypeptide, acute liver injury, protective capability

CLC Number:

TS201.4

FAN Ying，WANG Chang-qing*，WANG Fei，YU Shu-jia，LIAN Wei-shuai，YUAN Min. Protective Effect of Whey Protein and Polypeptide from Small Black Soybean on Acute Liver Injury in Mice[J]. FOOD SCIENCE, 2013, 34(5): 238-241.

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