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Acute and Genetic Toxicity of Total Flavonoids Extract of Artemisia selengensis

WU Yu-long, HUA Chun*, FU Qing-quan, WU Xiang-hua   

  1. School of Biochemical and Environmental Engineering, Nanjing Xiaozhuang University, Nanjing 211171, China
  • Online:2014-04-15 Published:2014-04-18


Objective: To evaluate the safety of total flavonoids extract of Artemisia selengensis for consumption. Methods:Acute toxicity test, micronuclear test in polychromatic erythrocytes of bone marrow and sperm abnormality in mice, bonemarrow chromosome aberration test in mice and Ames test were conducted to investigate the acute and genetic toxicity ofthe total flavonoids extract. Results: For the acute toxicity, the LD50 was > 10 g/kg. No apigenin-related genetic toxicity wasobserved. Conclusion: Under the conditions of this experiment, the total flavonoids extract has neither acute nor genetictoxicity.

Key words: Artemisia selengensis, total flavonoids, acute toxicity, genetic toxicity