Abstract:

Objective: To reveal the preventive effect of jujube polysaccharides (JP) on chronic fatigue syndrome (CFS).
Methods: JP were prepared from jujube fruits by water extraction and ethanol precipitation and their physicochemical
properties were determined. A four-week old rat CFS model was established. The rats were orally administrated with JP
and the behavior experiments were conducted after induction of CFS. The activities of superoxide dismutase (SOD) and
glutathione peroxidase (GSH-Px), and the levels of malondialdehyde (MDA) in rat serum were eassayed. Spleen index,
thymus index and T lymohocyte transformation were analyzed. Results: JP markedly decreased MDA levels in serum, and
increased spleen index and T lymohocyte transformation. Conclusions: The preventive effects of JP on CFS are closely
related to their immune-regulating function and antioxidant activity.

Key words: jujube polysaccharide, chronic fatigue, immune, antioxidant