Antioxidant Activity and Inhibitory Activity of Ethanol Extract from Ficus auriculata Fruits against α-Glucosidase and Acetylcholine Esterase

doi:10.7506/spkx1002-6630-201613014

Abstract

Abstract:

Total phenolics were extracted from Ficus auriculata fruits using 65% ethanol and quantified by the Folin phenol
method. The antioxidant activity of the ethanol extract was assessed by DPPH, ABTS and hydroxyl radical scavenging
assays and its inhibitory activity against alpha-glucosidase and acetylcholine esterase was also evaluated. Results showed
that the fruit extract contained high levels of total phenolics (1.92 mg/g DW) and could scavenge DPPH, ABTS and hydroxyl
radicals effectively in a concentration dependent manner with IC50 of 141.25, 91.20 and 45.71 μg/mL, respectively. It also
exhibited strong inhibitory activity against α-glucosidase in a concentration dependent manner with IC50 of 102.33 μg/mL.
Similarly, it showed inhibitory activity against acetylcholine esterase with IC50 of 4.9 mg/mL. Therefore, the polyphenolrich
extract from Ficus auriculata fruits has strong antioxidant potential and inhibitory activity against α-glucosidase and
acetylcholine esterase.

Key words: Ficus auriculata, fruit polyphenols, antioxidant activity, radical scavenging activity, α-glucosidase inhibitory activity, acetylcholine esterase inhibitory activity

CLC Number:

S663.9

TAN Lin, ZHENG Xiaoyan, WANG Jiashui, MA Funing, KANG Youfa, ZANG Xiaoping, MA Weihong. Antioxidant Activity and Inhibitory Activity of Ethanol Extract from Ficus auriculata Fruits against α-Glucosidase and Acetylcholine Esterase[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201613014.

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