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Hypolipemic Effect of Acidic Polysaccharides from Auricularia auricula on Hyperlipidemia Mice

YU Meihui1, ZHAO Xin1, YIN Hongli2, LIU Ran3, WANG Zhenyu4,*   

  1. 1. School of Forestry, Northeast Forestry University, Harbin 150040, China; 2. Institute of Staple Food Processing Technology, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Harbin 151900, China; 3. College of Agriculture, Liaocheng University, Liaocheng 252000, China; 4. School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China
  • Online:2016-08-15 Published:2016-08-30

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Abstract:

Objective: To explore the lipid-lowering effect of acidic polysaccharides from Auricularia auricula in
hyperlipidemia mice. Methods: Acidic polysaccharides from Auricularia at different doses were intragastrically
given to hyperlipidemic model mice to explore their effects on blood lipids and related enzymes. Results: Compared
with the model group, the body weight of the treated mice decreased obviously, liver index and atherosclerosis index
(AI) as well as serum TC and TG levels similarly declined obviously, whereas HDL-C levels increased significantly
(P < 0.01 or 0.05). Moreover, total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) activities in the
middle and high dose treatment groups were significantly higher than those in the model group (P < 0.01). Conclusion:
Acidic polysaccharides from Auricularia auricula can significantly reduce blood lipid levels, fat accumulation in liver and
artery atherosclerosis caused by excessive lipid intake in hyperlipidemia mice and protect against lipid peroxidation damage
caused by hyperlipidemia.

Key words: acidic polysaccharides from Auricularia auricula, blood fat, hypolipemic effect

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