Abstract:

A large number of studies have shown that lactic acid metabolism flux can be used to quantitatively describe
the state of the body in the condition of normal life. When it is reduced, the body is in good shape; in contrast, when it is
increased, the body is in the state of inflammation or detoxification. In recent years, a number of reports have demonstrated
the prevention of diseases of modern civilization by resveratrol and it is evident that this effect is closely related to lactate
metabolism flux. However, studies on its metabolism in the body have rarely been reported. In the present study, one control
group and three resveratrol treatment groups at low, medium and high doses (2, 20 and 200 mg/kg), each consisting of 6 male
rats were designed. After the rats were administered by gavage, a metabolic network model for metabolic flux analysis was
established. The results showed that the body catabolism was reduced by administration of 2 mg/kg of resveratrol, but it was
increased dose-dependently when the dose was over 20 mg/kg. Based on these results, resveratrol at 2 mg/kg could result
in the lowest body catabolism, suggesting that it can help prevent and treat diseases of modern civilization. As it resulted in
a significant increase in the body catabolism, resveratrol at 200 mg/kg could cause toxic side effects to the body. Therefore,
resveratrol can play a role in protecting the body against diseases only in a certain dose range.

Key words: resveratrol, metabolic flux, rat