Abstract: A headspace-gas chromatography-mass spectrometry (SHS-GC-MS) method was presented for simultaneous determination of 14?toxic volatile organic?solvent residues?(dichloromethane, trichloromethane, 1,2-dichloroethane, benzene, carbontetrachloride, trichloroethylene, methylbenzene, tetrachloroethylene, chlorobenzene, ethylbenzene, m-xylene, p-xylene, o-xylene, and isopropylbenzene) in flavors and fragrances. The headspace conditions including equilibrium temperature and time and the instrumental conditions were optimized. Samples were subjected to headspace extraction at 80 ℃ for 30 min and the extract was then separated on an HP-1 capillary column. and detected by GC-MS in the selected ion monitoring (SIM) mode. The results showed that in the range of 0.5–50 μg/L, all of the calibration curves displayed good linearity with correlation coefficients of higher than 0.998. The average?recoveries of spiked samples were 71.7%–101.0% with?relative standard deviation (RSD) between 1.71% and 9.29%. The limits of detection (LODs) were 1.0–10.0 ng/g.

Key words: volatile organic solvent (VOC), static headspace (SHS), gas chromatography-mass spectrometry (GC-MS), flavors and fragrances