FOOD SCIENCE ›› 2020, Vol. 41 ›› Issue (1): 196-202.doi: 10.7506/spkx1002-6630-20181207-088

• Nutrition & Hygiene • Previous Articles     Next Articles

Probiotic Effects of Two Lactobacillus Strains in Rats Fed a High-Fat Diet

ZHU Jiexu, GAO Li’e, HUANG Wenkang, LI Wenyuan, MA Ying, GUO Xusheng, DING Zitong   

  1. (Probiotics and Bio-feed Research Centre, School of the Life Sciences, Lanzhou University, Lanzhou 730000, China)
  • Online:2020-01-15 Published:2020-01-19

Abstract: The objective of this study was to investigate the probiotic effects of two cholesterol-lowering lactic acid bacterial strains isolated from traditional fermented yak milk in the Tibetan plateau in rats fed a high-fat diet. It has been proved that Lactobacillus helveticus BX-1 could produce bile salt hydrolase while Lactobacillus reuteri BX56 could not. Administration of strain BX-1 could significantly reduce cholesterol and triglycerides in the serum and liver of rats (P < 0.05), reduce lipid deposition in the liver, and accelerate the excretion of lipids at the same time. However, BX56 had no significant effect in lowering cholesterol in rats. Overall, BX-1 has a good cholesterol-lowering capacity and may have a potential in hyperlipidemia treatment.

Key words: lactic acid bacteria, rats, cholesterol-lowering activity, probiotics

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