FOOD SCIENCE ›› 2020, Vol. 41 ›› Issue (21): 259-266.doi: 10.7506/spkx1002-6630-20191115-185

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Recent Progress in Deciphering the Regulatory Mechanism of Lactic Acid Bacteria on Mitochondrial Biogenesis in Skeletal Muscle

BAI Yanping, HOU Yanru, HOU Puxin, SUN Bing, ZHAO Lihua, BA Jimuse, JIN Ye, SU Lin   

  1. 1. College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China; 2. Agriculture, Animal Husbandry and Technology Bureau, Wulate Middle Banner 015300, China
  • Published:2020-11-23

Abstract: As highly dynamic organelles, mitochondria are in continuous dynamic change. Mitochondrial biogenesis is crucial to maintain mitochondrial network homeostasis, and is also a new medium to regulate the transformation of muscle fibers. Lactic acid bacteria can promote mitochondrial biogenesis by inducing the activation of intracellular kinase in skeletal muscle cells, enhancing signal induction of reactive oxygen species and peroxisome proliferator-activated receptor gamma co-activator-1α transcription, thereby affecting the transformation of muscle fiber types. The type of skeletal muscle fibers is closely related to muscle quality. Therefore, the regulation of mitochondrial biogenesis by lactic acid bacteria to affect the transformation of muscle fiber types is considered an important way to improve meat quality in the future. This paper reviews the molecular mechanism by which lactic acid bacteria can regulate mitochondrial biogenesis in skeletal muscle, and the relationship of mitochondrial biogenesis with muscle fiber transformation and meat quality, which will provide a theoretical rationale for regulating mitochondrial biogenesis and promoting muscle fiber type transformation in order to improve meat quality by supplementing lactic acid bacteria in the future.

Key words: lactic acid bacteria; skeletal muscle; mitochondrial biogenesis; muscle fiber type; meat quality

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