FOOD SCIENCE ›› 2021, Vol. 42 ›› Issue (13): 136-142.doi: 10.7506/spkx1002-6630-20200715-210
• Nutrition & Hygiene • Previous Articles Next Articles
ZHAO Xiao, XU Jinghan, CUI Dongying, XU Jinzhao, LIU Yang, TENG Guoxin, XU Xiaoxi
Online:
Published:
Abstract: The effect of lactoferrin (LF) on the α-diversity and composition, as well as the abundance of KEGG signaling pathway-related operational taxonomic unit (OTU) in the colonic microbiota of rats with inflammatory bowel disease (IBD) induced by dextran sulphate sodium (DSS) was analyzed by high-throughput sequencing. The results showed that LF alleviated the reduction of α-diversity and the imbalance between the dominant phyla Firmicutes and Bacteroidetes caused by DSS stimulation. LF increased the abundance of Lactobacillaceae (12% vs. 40%) and Ruminococcaceae (17% vs. 27%), and decreased Bacteroides (28% vs. 8%) and Prevotellaceae (13% vs. 6%). LF administration reduced the abundance of OTUs associated with human diseases such as cancer and infectious diseases, immune system, cells and genetics-related signaling pathways in the gut microbiota in IBD rats. The results of this study indicated that LF can play a beneficial role in regulating the colonic micro-ecology of IBD rats and modulating the microbiota composition to be similar to that of healthy rats, thereby having the potential to reduce the risk of other concomitant diseases.
Key words: lactoferrin; gut microbiota; inflammatory bowel disease; SD rats; KEGG signaling pathway
CLC Number:
TS252.1
ZHAO Xiao, XU Jinghan, CUI Dongying, XU Jinzhao, LIU Yang, TENG Guoxin, XU Xiaoxi. Positive Regulation of Lactoferrin on Gut Micro-Ecology of Rats with Inflammatory Bowel Disease[J]. FOOD SCIENCE, 2021, 42(13): 136-142.
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URL: https://www.spkx.net.cn/EN/10.7506/spkx1002-6630-20200715-210
https://www.spkx.net.cn/EN/Y2021/V42/I13/136