Recent Advances in in Vivo Metabolism and in Vitro Synthesis of Breast Milk Oligosaccharides

doi:10.7506/spkx1002-6630-20200925-315

Abstract

Abstract: Human milk oligosaccharides (HMOs) are unique nutrients in breast milk, which have complex and multifarious structures. Different HMOs may have different functions. In this article, we summarize the latest progress in understanding the individual difference, structural diversity and functional activity of HMOs. We put a special focus on the metabolic pathway in human body and the synthetic pathway in vitro of HMOs. Finally, we discuss the current status of the application of HMOs in infant formula and problems facing HMOs research and application. The application of HMOs in infant formula is a major breakthrough and it has great potential in narrowing the gap between formula-fed infants and breast-fed infants in intestinal flora composition, immune function and cognition capacity. In-depth studies of HMOs will offer the theoretical basis for the developement of new infant formula.

Key words: human milk oligosaccharides; structural diversity; metabolism; synthesis; probiotics; current applications

CLC Number:

TS201.2

CHEN Qingxue, SHI Fengyi, ZHAO Lina, LIANG Shengnan, Masumuzzanm MD, HUO Guicheng, LI Bailiang. Recent Advances in in Vivo Metabolism and in Vitro Synthesis of Breast Milk Oligosaccharides[J]. FOOD SCIENCE, 2021, 42(19): 379-387.

[1]	Miao-Miao Liu Junrong Huang. Regulation of functional properties of myofibrillar protein and quality of meat products by basic amino acid: A comprehensive review [J]. FOOD SCIENCE, 0, (): 0-0.
[2]	. Dynamic Changes of Taste Compounds and Evaluation on Umami during Vacuum Freeze-drying of Lentinula edodes [J]. , 0, (): 0-0.
[3]	. Based on HS-SPME/GC-MS and electronic nose technology to study the aroma compounds of peach of different flesh types during postharvest storage [J]. FOOD SCIENCE, 0, (): 0-0.
[4]	. Physicochemical characterization and emulsification properties of Cerasus humilis Pectin [J]. , 0, (): 0-0.
[5]	Li Ting Bo Zou Yujuan Xu Man-qin FU Linda CHENG. Structural identification and antioxidative mechanism of dietary polyphenols in fruit pulp of pomelo [J]. FOOD SCIENCE, 0, (): 0-0.
[6]	. Formation and Involved Mechanism of Soy Protein-based Nanoparticles via Controlled Alcalase Hydrolysis [J]. FOOD SCIENCE, 0, (): 0-0.
[7]	Kun YANG yanan shi Qiong ZHAO. The mechanism of antimicrobial peptide BCp12 on E.coli wall membrane and DNA damage [J]. , 0, (): 0-0.
[8]	Fang Yuan. Preparation and stability evaluation of novel lycopene microcapsules [J]. , 0, (): 0-0.
[9]	Miao-Miao Liu Junrong Huang. Advance in Synthesis, Purification Technologies and Physiological Activities of AcEGCG: A Review [J]. FOOD SCIENCE, 0, (): 0-0.
[10]	. Review of Ferritin Nanocarrier Applications in the Field of Nutrition and Health [J]. FOOD SCIENCE, 0, (): 0-0.
[11]	Rui Yang. Covalent interaction between hesperidin and ferritin and its effect on the physicochemical properties of ferritin [J]. , 0, (): 0-0.
[12]	Jing ZHAO. Comparison of Determination Method for Anthocyanins Quantitative in Black Chokeberry [J]. , 0, (): 0-0.
[13]	. Preparation and evaluation of α-tocopherol-loaded solid lipid nanoparticles from shea butter [J]. , 0, (): 0-0.
[14]	Jia Lin LIU JIn Zhengyu. Research progress on enzymatic synthesis of glycogen-like α-glucan [J]. , 0, (): 0-0.
[15]	yu OUYANG 权 kuoZHAO na yingFENG zhang liang Wu qian. Biological activity and potential health risks of Maillard reaction products [J]. , 0, (): 0-0.

Recent Advances in in Vivo Metabolism and in Vitro Synthesis of Breast Milk Oligosaccharides

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