Abstract: Fucoidin (FD) was extracted and purified with DEAE-cellulose column from Laminaria Japonica Aresch.Wistar rats were divided into 5 groups (A,B,C,D,and E).FD was administered (ig) to A,B,and C group at the dose of 50,150 and 300mg/kg.d respectively.The former four groups (A,B,C and D) were given high fat emulsion for 15 days,and E group was given the equal volume water.Then serum lipidperoxide and lipids were determined.The results were as follows:TC,TG,LDL-C,LDL-C/HDL-C and TC/HDL-C remarkably decreased with the increase of HDL-C and LPO level obviously dropped in A,B, and C group ,in comparision with D group.The results also showed that lipids level dropped much more with the increased of FD dose but no significant difference was found between the dose of 150 and 300mg/kg.TC droped by 41.7%,TG by 35.9% for the dose of 150mg/kg,whereas TC dropped by 28.4%,and TG by 29.0% at the dose of 50mg/kg.FD (ig 150 and 300mg/kg) also effectively restrained the increase in body weight induced by high fat emulsion.

Key words: Fucoidin Hyperlipidaemia