Abstract: Compared with some traditional thrombolytics, nattokinase, which is found to be a strong fibrinolytic enzyme, is safer in use at a lower-cost. It is effecive by oral administration, and expected to be a new thrombolytics. Its isolation、purification、and characteristics were introduced in this paper. It also reviewed the newly studies on its activity detection、stability factors and high production technology.

Key words: Nattokinase , Activity detection , Stability factors , High production