The Effect of Carotenoid on the DNA Damage of Breast Cancer Cell of MDA-MB-435S

Abstract

Abstract: Objective:To observe the effect of carotenoids on the DNA damage of breast cancer cell of MDA-MB-435S.Methods:The breast cancer cells MDA-MB-435S were cultured with carotenoids in vitro.The DNA damage of breast cancercells was determined by the single cell gel electrophoresis assay.Results:β- carotene and astaxanthin could induce the DNAdamage of breast cancer cell-lines MDA-MB-435S and show dose-response and time-response relationship.Lycopene couldinduce the DNA damage of breast cancer cell-lines MDA-MB-435S,while canthaxanthin,zeaxanthin and zeaxanthin dipalmitatecould not induce the DNA damage of breast cancer cell-lines MDA-MB-435S.

Key words: carotenoids, breast cancer cells, DNA damage

PENG Guang-Hua, LI Zhong, QI Xiang-Yang, ZHANG Sheng-Hua. The Effect of Carotenoid on the DNA Damage of Breast Cancer Cell of MDA-MB-435S[J]. FOOD SCIENCE, 2003, 24(9): 124-127.

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The Effect of Carotenoid on the DNA Damage of Breast Cancer Cell of MDA-MB-435S

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