Anticancer Effects and Possible Mechanism of Antibacterial Components from Allium chinense

Abstract

Abstract: This study showed that the antibacterial components from Allium chinense kept stable under different temperature.After treated by the components, the proliferation of HepG-2 and Hela cells were inhibited and their cell cycle distribution werechanged. Analysis revealed that the components didn’t induce apoptosis. The components had more inhibitive effect on the enzymeactivity of papain than on proteinase K in vitro. The possible anticancer mechanism of the components was that the activity of somemercapto enzymes such as papain in cancer cells were inhibited by the components.

Key words: Allium chinense, antibacterial components, anticancer, cell cycle distribution, papain

SUN Yun-Jun, BAI Jian-Shan, CHEN Yu, MENG Song, XIE Wei-An, DING Xue-Zhi, MO Xiang-Tao, XIA Li-Qiu. Anticancer Effects and Possible Mechanism of Antibacterial Components from Allium chinense[J]. FOOD SCIENCE, 2004, 25(11): 295-299.

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Anticancer Effects and Possible Mechanism of Antibacterial Components from Allium chinense

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