Hypertension Lowering Study on L-nitro-arginine Hypertension Model Rats by Monascus Administration

Abstract

Abstract: The purpose of the Study was to investigate the effect of monascus on lowering hypertension and the changes ofplasma endothelin (ET) value and calcitonin gene-related peptide(CGRP)value in L-nitro-arginine(L-NNA)hypertension modelrats. There were 20 male Wistar rats divided into 3 groups:control group(group C)8 cases,L-NNA hypertension group(groupL)6 cases and L-NNA+monascus group(group L+M)6 cases. The results showed ET and ET/CGRP were increased markedlyin L-NNA hypertension model rats(p<0.05), while CGRP showed no significant difference between group C and group L(p=0.8342).ET was reduced remarkably in L+M group(p<0.001).Therefore,increasing ET and ET/CGRP might lead to thehypertension of rats. Monascus could lower hypertension by reducing blood ET value.

Key words: monascus, endothelin, calctionin gene-related peptide, hypertension, L-NNA

TANG Fen-Fang, ZHANG Jing, ZOU Jie, SUN Wei, JIAO Xiao-Hui, JIN Zong-Lian. Hypertension Lowering Study on L-nitro-arginine Hypertension Model Rats by Monascus Administration[J]. FOOD SCIENCE, 2004, 25(4): 155-157.

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Hypertension Lowering Study on L-nitro-arginine Hypertension Model Rats by Monascus Administration

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