Abstract: To study the security and decreasing blood lipid effect of seed oil of Nitraria tangutorum Bobr. from Qinghai Qaidam Basin, the seed oil extracted by supercritical CO2 fluid extraction (SFE-CO2) from Nitraria seeds was investigated for the acute toxicity and its security was evaluated. The blood lipid levels in the serum of each animal group with the hyperlipemia models of Wistart rat and Kunming strain mice induced by feed with high lipids were determined after oral administration for 4 weeks with the seed oil. It showed that the mice were secure by feeding the seed oil at the dose of 40ml/kg d after 14 days; but the seed oil of Nitraria tangutorum Bobr. fed at the dose of 5g/kg and 10g/kg not only showed significant inhibition effect on TC, TG and LDL levels in serum of hyperlipemia model of Wistar rat, but also increased the ratio of HDL/TC and HDL/LDL. That illustrated that the high dose of seed oil of Nitraria tangutorum Bobr. has the decreasing blood lipid effect.

Key words: Nitraria tangutorum Bobr., Nitraria seed oil, security evaluation, decreasing blood lipid effect