Abstract: α-Tocopherol acid succinate is one of the important Vitamin E products and has a number of medical functions. This paper outlines the process development of α-tocopherol acid succinate synthesis by a single factor and orthogonal design experiments in which α-tocopherol reacted with the succinic anhydride. With this process, the esterification of α-tocopherol could exceed 90% by weight under optimum conditions.

Key words: α-tocopherol acid succinate