Abstract: A rapid determination of total momordicoside by ultrasonic extraction from bitter melon (Momordica charantia) was reported in this paper.In the operation of ultrasonic extraction,only 0.1g of sample and 2ml of 80% ethanol were used.Only 30min was necessary for the extraction.As compared with the conventional Soxhlet’s method,the ultrasonic extraction method required shorter extraction time, less solvent reagent and no heating. The determination efficiency of the ultrasonic method was 10 times higher than the Soxhlet,s method.There was no significant difference between the analytical results obtained by those two methods.

Key words: ultrasonic extraction, rapid determination, total momordicoside