Abstract: The blood glucose effects of various treatments, such as Ginkgo biloba leaf extract (EGB), biotransformation products of EGB by Hericium erinaceus, supernatant of submerged culture of H.erinaceus, the supernatant combined with EGB, and the control groups were compared in alloxan-induced hyperglycemic mice. The levels of blood glucose, lipid, fructosamine, and SOD activity in the model mice were measured after different treatments using samples above. Results showed that the biotransformation products of EGB by H.erinaceus, comparing with other groups, significantly reduced the levels of blood glucose, fructosamine, and increased the serum SOD activity and the body weights of the alloxan-induced mice. The results indicated that the blood glucose decreasing by biotransformation products of EGB was remarkably improved. Our investigations also provided useful information and references for screening the new herb products to control the diabetes and improving the effects of the herbs.

Key words: Ginkgo biloba L., extract, Hericium erinaceus, biotransformation, diabetes