Abstract: The mutagenic cell-L5178Y-3.7.2C cell-was treated with different concentrations of acrylamide (0.10, 0.25, 0.50 and 0.75mg/ml respectively). The results showed that with the increasing of the concentration of acrylamide, Relative Suspension Growth (RSG) decreases, and tk locus mutation frequency increases. Moreover, tk locus mutation frequency induced by 0.5, 0.75mg/ml of acrylamide is dosage-dependently higher than spontaneous mutation frequency. The results suggested that the acrylamide induces mutagenicity at higher concentration.

Key words: acrylamide, mutagenicity, tk mutation assay