Abstract: Objective: To investigate the activation effects of sepia product on hematopoietic function in 60Coγirradiated mice. Methods: Model mice of hematopoietic system impairment were induced by whole body 60Coγirradiaion with the lethal dose of 8.0 Gy and then given different dosage of sepia products respectively. Spleen and thymus indexes, numbers of bone marrow nucleated cells (BMNC), colony-forming units in spleen (CFU-S), colony-forming units of granulocyte and monocyte(CFU- GM), peripheral blood pictures and serum SOD activity in model mice were assayed respectively. Results: Sepia products could resist the decrease of BMNC(p<0.05, p<0.01), CFU-S(p<0.05, p<0.01), CFU-GM(p<0.01), and peripheral WBC (p <0.01) and promote the restoration of those indices mentioned above in model mice significantly (p<0.05, p<0.01), but have no significant effects on peripheral RBC, PLT and Hb respectively. Conclusion: Sepia production has significant promoting effects on hemapoiecsis.

Key words: sepia production； 60Co&gamma, irradiation impairment； hematopoitic function； SOD；