Effects of Rapeseed Polysaccharides（RSPS）on S180 Tumor Growth Inhibition and Immune Capability Enhancement in vivo

Abstract

Abstract: Effects and mechanism of RSPS on S180tumor growth inhibition were studied in this paper.The tumor-bearing mice were gained by being implanted S180cells inoculated in right front axillas.The S180-bearing mice were injected with physiological saline,cyclophosphamide and RSPS into its intra-peritoneal.The indexes were detected for the weight of rumor and immune organ, immune function and antioxidation capability.Results showed that RSPS could inhibit tumor growth in vivo and the inhibiting rate was between 20.66% and 34.71% at 50～200mg/kg·d of RSPS.RSPS could also enhance immune capability,thymus index,spleen index,macrophage phagocytic rate and phagocytic index,delayed-type hypersensitivity,splenic antibody formation and serum hemolysin content,while inhibit mice lactate dehydrogenase activity,improve the mice catalase activity and decrease the MDA content in mice serum.The tumor inhibiting mechanism of RSPS can promote immunocompetence and antioxidative activities and inhibition of lactate dehydrogenase.

Key words: rapeseed polysaccharides(RSPS), S180 tumor, tumor inhibition, immune capability, antioxidation

YAN Feng-Wei, WANG Chen, YAN Zan-Kai, WU Mou-Cheng. Effects of Rapeseed Polysaccharides（RSPS）on S180 Tumor Growth Inhibition and Immune Capability Enhancement in vivo[J]. FOOD SCIENCE, 2007, 28(4): 309-313.

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Effects of Rapeseed Polysaccharides（RSPS）on S180 Tumor Growth Inhibition and Immune Capability Enhancement in vivo

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