Study on Inhibition Effects of Quercetin-zinc Complex on Nitrosamine Synthesis in vivo and in vitro

Abstract

Abstract: To improve the solubility of quercetin in water,quercetin-zinc complex was synthesized.The activity of quercetin-zinc complex on inhibiting nitrosation was studied by blocking rate on synthesis of nitrosamine,formation of nitrite ion and scavenging rate under the condition of simulated gastric juice(pH3.0,37 ℃)in vitro in this paper.The activity of blocking synthesis of nitrosamine by experimental of small mice was investigsted in vivo,taking serum GPT as index.The results showed that quercetin-zinc complex has strong capability of blocking nitrosamine synthesis.The maximum blocking rate of NDMA is 91.70%,and the activity of scavenging sodium nitrite is obvious.The maximum eliminating rate of nitrite sodium is 80.64%.Quercetin-zinc complex inhibited nitrate ion reduced into nitrite ion by nitrate reductase,and the inhibitory rate amounted to 58.64%.During the process of blocking synthesis of nitrosamine,the serum GPT in quercetin-zinc complex group is significantly lower than those in control group(p<0.01).

Key words: quercetin-zinc complex, nitrite sodium, nitrosamine, nitrate reductase, inhibition

WU Chun, HUANG Mei-Gui. Study on Inhibition Effects of Quercetin-zinc Complex on Nitrosamine Synthesis in vivo and in vitro[J]. FOOD SCIENCE, 2007, 28(9): 35-38.

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Study on Inhibition Effects of Quercetin-zinc Complex on Nitrosamine Synthesis in vivo and in vitro

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