Abstract: High F value oligoeptide is a kind of small peptide mixture which contains 2 to 5 amino acid residues.It has the functions of anti-fatigue,anti-anoxic and other physiological function,and it also could be used in treament of hepatic encephalopathy as an auxiliary treatment.The effect of the high F value oligopeptide from egg white on the L-hydroxyproline content in skin of mice was investigated in this study,and a comprehensive analysis on the effects of high F value oligopeptide at different concentrations was carried out.The results showed that the high F value oligopeptide can significantly impove the content of L-hydroxyproline in skin of mice,especially when the concentration of high F value oligo-peptide is 10% no matter intragastric administration for 30 d or 90 d.

Key words: high F value oligopeptide, L-hydroxyproline, chloramine T